A ferret's fur will give you an indication if anything is wrong.

A ferret's coat should be shiny and thick, never dull or dry.

Hair loss, and texture and quality changes are causes for concern. External parasites such as fleas, ticks and mites can cause abnormalities, but they are usually visible to the naked eye. The most common cause for hair loss in a mature, neutered ferret is adrenal disease. The most common cause for hair loss in an intact female ferret during its reproductive active cycle is a hormonal imbalance.

Normal ferret skin is smooth and pink without flakes, scabs or discoloration. In the wild, ferrets would spend a portion of their day in underground dens, where there is a constant temperature of 55 degrees with high humidity. In our homes in the winter, the air can be very dry and warm, which can dehydrate the ferret's skin. A cool home humidifier can help.

Your veterinarian should investigate any lumps, scabs or discoloration of the skin as soon as possible. Skin cancer is a common problem in ferrets and can be successfully cured with early treatment.